SHENG Xiuzhen, WANG Jincheng, TANG Xiaoqian, XING Jing, CHI Heng, ZHAN Wenbin. Research progresses of nasal-associated lymphoid tissue in fish[J]. Journal of fisheries of china. DOI: 10.11964/jfc.20221213859
Citation: SHENG Xiuzhen, WANG Jincheng, TANG Xiaoqian, XING Jing, CHI Heng, ZHAN Wenbin. Research progresses of nasal-associated lymphoid tissue in fish[J]. Journal of fisheries of china. DOI: 10.11964/jfc.20221213859

Research progresses of nasal-associated lymphoid tissue in fish

  • The mucosa-associated lymphoid tissue of fish is the first line of defense against pathogens. Among them, the nasal-associated lymphoid tissue (NALT) of fish has attracted the worldwide attention in recent years, and has been proved to be an important place for antigen recognition and initiation of mucosal immune response in olfactory organs. NALT exerts a rapid local immune response following bacterial, viral and parasitic infections. Intranasal vaccination of fish targeted NALT can provide excellent immune protection. However, it is largely unknown about the complex network of cells and molecules in NALT and their interaction mechanisms. Here, the latest research progress on the structure and function of olfactory organ, cellular and molecular networks and immune response of NALT, response to intranasal inoculation and immunoprotective effect of fish are reviewed. These information will promote understanding of the immune defense mechanism exerted by fish NALT locally in the mucosa, which will benefit the design and development of novel mucosal vaccines.
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