Abstract: White spot syndrome virus (WSSV) remains a major constraint to shrimp aquaculture, and water temperature can substantially shape infection outcomes. This review synthesizes experimental and application-oriented evidence on heating-based temperature intervention, with emphasis on mechanistic support levels, operational parameters, and practical boundaries across farming systems. We compared temperature setpoints, intervention timing and holding duration, heating patterns, water-quality context, and outcome metrics including viral load, survival/mortality, histopathology, and stress/immune indicators. Overall, a thermal window of 32–33 °C is most frequently associated with suppressed viral amplification and improved survival, yet the effects are strongly condition-dependent, being sensitive to host species and stage, temperature–time combinations, oxygen and nitrogenous wastes, and system controllability. Mechanistically, the most consistent causal support centers on host stress-associated factors (e.g., HSF1–Hsp70–linked signaling) coupled with antiviral outcomes, whereas broader pathway-level claims require further validation under standardized heating protocols. Heating intervention should therefore be framed as a risk-management tool for replication suppression, viral-load reduction, and outbreak delay rather than assured pathogen eradication. Standardized infection models and multi-metric evaluation are recommended to define safe operable ranges and triggers and to support an operational workflow of monitoring-triggered heating, holding, recovery, and re-testing for practical biosecurity and health management.