Abstract: In recent years, as bullfrog (Rana catesbeiana) farming grows, optimizing feed composition has become essential. While nutrients like protein and lipids have been extensively studied, the carbohydrate component remains relatively under-researched. To fill this gap, a 56-day feeding trial was conducted on R. catesbeiana to compare corn meal and wheat meal as dietary starch sources at inclusion levels of 18%, 22%, or 26%, yielding 6 isonitrogenous, isolipidic diets (C18, C22, C26 vs F18, F22, F26). R. catesbeiana fed corn meal diets showed significantly higher final body weight, particularly at the 22% inclusion level, compared to those fed wheat meal (P<0.05). Serum glucose (GLU) and total bile acid (TBA) levels increased with higher dietary starch, but at each inclusion level they were significantly lower in corn meal-fed R. catesbeiana than in wheat meal-fed R. catesbeiana (P<0.05), indicating more stable glycemic control with corn meal. High wheat meal intake led to elevated total cholesterol (T-CHO) and LDL-C levels, accompanied by a reduction in HDL-C, while corn meal diets showed the opposite pattern (lower LDL-C and higher HDL-C at 26% inclusion) (P<0.05). Hepatic pyruvate dehydrogenase (PDH) activity rose with increasing corn meal level, whereas succinate dehydrogenase (SDH) activity remained unchanged across diets. Both liver glycogen and hepatic lipid content increased with dietary starch level (P<0.05); however, corn meal-fed R. catesbeiana showed significantly lower hepatic glycogen and lipid accumulation than wheat meal-fed R. catesbeiana at the same meal levels (P<0.05). Corn meal-fed R. catesbeiana also exhibited lower muscle glycogen than wheat meal-fed R. catesbeiana at the 26% starch level (P<0.05). Intestinal digestive enzyme assays indicated that α-amylase activity was higher at lower starch inclusion and slightly higher in wheat meal-fed R. catesbeiana at 22% (P<0.05), whereas lipase and trypsin activities were not significantly affected by diet. Gene expression analysis showed that higher starch intake upregulated hepatic pfk (phosphofructokinase) and downregulated igfbp1 (P<0.05). Notably, the high wheat meal diet (F26) induced a significant increase in hepatic gluconeogenic g6pc expression that was not observed in corn meal-fed groups (P<0.05). In conclusion, corn meal-especially at 22% inclusion-resulted in better growth, more stable glucose metabolism, lower hepatic lipid accumulation, and more favorable metabolic gene expression profiles compared to wheat meal.