Abstract: In order to improve the economic benefits of aquaculture, it is important for famers to fully understand the bio-economic laws of the species which is farmed. Taking Lateolabrax maculatus as an example, based on household interview data and results from literatures, a multi-batch non-uniform cycle linear programming bio-economic model was established, and the common November (early batch), December (middle batch), March-April (last batch) single batch and different batch seedling combination strategies in breeding were simulated in parameterized scenarios to seek the optimal breeding strategy. The study found that: ① Generally speaking, the combination strategy of different batches of seedlings is better than the single batch of seedlings, and exceptions will only occur when the latter has a price advantage or yield advantage; ② Compared with the strategy of using a single batch of seedlings, the strategy of using different batches of seedlings can disperse the cash flow in the breeding process, speed up the return of funds, and reduce uncertainty risks; ③ The net present value of aquaculture is very sensitive to the changes of such parameters as the unit price of sales, the density of aquaculture and the instantaneous mortality in aquaculture production. Considering the yield, the product price and cash flow together, (1 _ 0 _ 5) and (0 _ 6 _ 0) are the optimal strategies for seedling feeding, which can guarantee higher yield and more cash inflow than other strategies no matter how the price fluctuates at the end of the batch. This research preliminarily revealed the bio-economic laws of L. maculatus farming, provides a basis for subsequent related research, and also provides decision-making support for stakeholders in the L. maculatus farming industry.